Should you create subdomains for each site, for each division, or even for each department? You have a lot of latitude in your choice because of DNS's scalability. You can create a few large subdomains or many small subdomains. There are trade-offs whichever you choose, though.
Delegating to a few large subdomains isn't much work for the parent because there's not much delegation to keep track of. However, you wind up with larger subdomains, which require more memory to load and faster name servers, and administration isn't as distributed. If you implement site-level subdomains, for example, you may force autonomous or unrelated groups at a site to share a single zone and a single point of administration.
Delegating to many smaller subdomains can be a headache for the administrator of the parent. Keeping delegation data current involves keeping track of which hosts run name servers and which zones they're authoritative for. The data changes each time a subdomain adds a new name server, or when the address of a name server for the subdomain changes. If the subdomains are all administered by different people, that means more administrators to train, more relationships for the parent's administrator to maintain, and more overhead for the organization overall. On the other hand, the subdomains are smaller and easier to manage, and the administration is more widely distributed, allowing closer management of zone data.
Given the advantages and disadvantages of either alternative, it may seem difficult to make a choice. Actually, though, there's probably a natural division in your organization. Some companies manage computers and networks at the site level; others have decentralized, relatively autonomous workgroups that manage everything themselves. Here are a few basic rules to help you find the right way to carve up your namespace: